VIRAL LOAD

Lab21 utilises Roche Diagnostic's FDA and CE-IVD-approved COBAS technology to produce fully-automated real-time PCR viral load results in its ISO 9001:2000 certified laboratory.

We can also process your CD4/CD8 samples and provide the results on a combined VL/CD4 report (click here for details).

Turnaround time - 5 working days

Technology

Fully automated Real-Time PCR Roche COBAS AmpliPrep (FDA/CE-IVD approved) Roche COBAS TaqMan (CE-IVD approved) Roche HIV-1 viral load assay (CE-IVD approved)

VIRAL RESISTANCE TESTING

Virco®TYPE HIV-1 is a clinically validated HIV-1 resistance test performed on plasma samples. It combines genotype and phenotype with additional clinical information, all in one easy-to-use report. Virco®TYPE HIV-1 is exclusively available from Lab21 in the UK and Ireland.

Genotypic information provided by the test

• • Drug resistance – associated mutations in the protease and reverse transcriptase genes in viral genes, grouped by drug class (NRTI/NtRI, NNRTI and PI)
• • A list of all differences from the reference wild type HXB2 virus

Phenotypic information provided by the test
virco®TYPE HIV-1 is the first HIV-1 drug resistance test using internationally agreed Clinical Cut-Off Values (CCOs). Based on the viral genotype, the test predicts:

• • Resistance to HIV drugs
• • Cross resistance

Virco®TYPE HIV-1 was developed by Virco BVBA, Belgium, and is performed in collaboration with Virco and Lab21 in the UK.

For further details on these products please visit: www.vircolab.com

TROPISM

HIV Tropism Testing

Monogram’s HIV Trofile™ Test – a companion diagnostic for Pfizer’s Celsentri™ and other HIV entry-inhibitor drugs

The Trofile™ Test is a new companion diagnostic used in the patient selection process for Pfizer’s new antiretroviral treatment for HIV, Celsentri™. Monogram’s HIV Trofile™ assay is only available through Lab21 in the UK and Ireland.

Celsentri™ is the first in its class of new HIV entry inhibitors, HIV patients should be pre-screened for the “tropism” of their virus prior to initiation of therapy. Monogram’s Trofile™ assay is the only clinically validated way to determine this.
The test establishes which co-receptor a person’s HIV uses, and therefore whether maraviroc (Celsentri™, Pfizer) and similar drugs are likely to work for that individual.

Lab21 ensures that samples are properly collected and rapidly transported to testing facilities at Monogram’s laboratory in South San Francisco. Lab21 facilitates the reporting of results to the clinic as efficiently as possible, and ensures that Trofile™ is available for patients across the UK and Ireland.

Source http://www.lab21.com/healthcare/trofile.php